Chlorhydrate d'irinotécan

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Chlorhydrate d'irinotécan

API

N° CAS 100286-90-6

Antineoplastic drugs

  • Irinotecan hydrochloride is the hydrochloride salt form of irinotecan, a pro-drug whose active metabolite inhibits topoisomerase 1.
  • Yellow crystalline powder.
  • It is a pro-drug activated by carboxylesterase preferentially in tumor tissue to an active metabolite, SN-38 inhibiting topoisomerase 1. Inhibition of topoisomerase I results in single-strand DNA breaks that block DNA replication.

Origine : Chemical

Formule : C33H39ClN4O6

Masse moléculaire : 623,1 g/mol

Pharmacopée : USP

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