Fluconazole

API

N° CAS 86386-73-4

Antifungals for dermatological use

• Fluconazole is a systemic antifungal drug, related to the imidazole family.
• A white or almost white, hygoscopic, crystalline powder. Slightly soluble in water, freely soluble in methanol, soluble in acetone.
• It inhibits the fungal cytochrome P450 14?-demethylase enzyme. This inhibition prevents the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane, and the subsequent accumulation of 14methyl-methyl sterols.