Irinotécan

API

N° CAS 97682-44-5

Antineoplastic drugs

• Irinotecan is a pro-drug whose active metabolite inhibits topoisomerase 1.
• It is a pro-drug activated by carboxylesterase preferentially in tumor tissue to an active metabolite, SN-38 inhibiting topoisomerase 1. Inhibition of topoisomerase I results in single-strand DNA breaks that block DNA replication.