N° CAS 97682-44-5
- Irinotecan is a pro-drug whose active metabolite inhibits topoisomerase 1.
- It is a pro-drug activated by carboxylesterase preferentially in tumor tissue to an active metabolite, SN-38 inhibiting topoisomerase 1. Inhibition of topoisomerase I results in single-strand DNA breaks that block DNA replication.
Formule : C33H38N4O6
Masse moléculaire : 586,68 g/mol
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